Ikeolu was born in Nigeria and came to the United States at age 13.
As an undergraduate at Harvard University, Iké volunteered as an English teacher for recent immigrants. She also interned at Greater Boston Legal Services, providing housing advocacy to economically disadvantaged clients. She attended Harvard Law School, where she was a submissions editor for the International Law Journal and co-president of the International Law Society.
Iké formerly worked in the Project Finance group of Skadden Arps in Washington, DC and then was Senior International Attorney with the Millennium Challenge Corporation. She still works with a nonprofit she co-founded with other young Nigerian immigrants designed to provide ways for Nigerians abroad to develop and contribute to youth programs in Nigeria.
Ike is married to Oreoluwa Adeyemi.