Thank you, I'm thrilled to be awarded this opportunity! I am just finishing up my second year of medical school and about to start graduate school in the PhD program in Biophysics at Stanford.
My work is jointly advised by Dr. Roger Kornberg at Stanford University and Dr. Erez Lieberman Aiden at Baylor College of Medicine.
The Hertz Fellowship will be supporting my work on understanding how the genome is physically organized inside cells. If you were to take the DNA inside a cell and stretch it out, it would measure over 6 feet long, and yet it fits inside a nucleus that is only microns wide. Understanding how this tremendous feat of packaging is accomplished is crucial to understanding how a heart cell, or an eye cell, or any other cell accomplish all of their vastly different functions despite having the same underlying DNA. I develop technologies to read and write the three dimensional structure of the genome in order to elucidate how all the components inside the nucleus come together to regulate biological processes like gene expression and establish cell state.
As with the PD Soros Fellowship, the most exciting part about receiving the Hertz Fellowship is the wonderful community that I'll be joining. Many of the scientists who I've been inspired by and have influenced my work are current or former Hertz Fellows; having the opportunity to interact with and learn from all of these scientists and be exposed to all the immensely creative ideas that are generated by members of the Hertz community is a true privilege.
As a future physician-scientist, my work is motivated by a desire to make a difference in the lives of patients. Our technological ability to sequence patients' genomes in the clinic is advancing tremendously, but there is still a major gap in our ability to analyze that information and use it to effectively inform clinical decisions. My hope is that my work on understanding the physical processes underpinning gene regulation will contribute to a better understanding of how to interpret variation in the genome and connect variation with more precise therapeutic modalities.